Aegis Summit 2025: Faith, Hope, Science - How Mayo Clinic Reinvented Itself, Dr. John Noseworthy

Recorded at the 2025 Aegis Summit, Dr. John Noseworthy - President & CEO Emeritus of Mayo Clinic and Chairman of the Aegis Digital Consortium - shares a four-part leadership story of transformation at one of the world’s most respected health systems. He traces Mayo’s cultural “superpower” (“the needs of the patient come first”), the moment the organization recognized it had to evolve, and the multi-year turnaround that followed: board-backed strategy, enterprise-wide operational redesign, a shift from quiet excellence to transparent excellence, and the deliberate creation of an entrepreneurial culture. Dr. Noseworthy offers practical lessons on governance (never surprise your board), storytelling, and sustaining momentum, and reflects on the Ken Burns documentary Mayo Clinic: Faith, Hope, Science as a catalyst for pride and change. This is a candid blueprint for leaders pursuing quality, growth, and mission—without losing sight of purpose.